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HomeProduct name listtert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Structural

What is tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate?

Synthesis

To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Reactions

Tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate is an crucial organic compound that can be used to synthesize 3-Amino-cyclobutaneMethanol hydrochloride.
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Properties of tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Boiling point: 317.9±11.0 °C(Predicted)
Density  1.08±0.1 g/cm3(Predicted)
pka 12.42±0.40(Predicted)

Safety information for tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

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