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HomeProduct name listTERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Structural

What is TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA?

Description

Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

The Uses of TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

  • Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
  • Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
  • Synthesis of polycationic adamantane-based dendrons for cell imaging.
  • Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

Properties of TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

Boiling point: 358.5±27.0 °C(Predicted)
Density  1.029±0.06 g/cm3(Predicted)
Flash point: 169.7 °C
storage temp.  -20°C
pka 8.74±0.10(Predicted)
color  Clear

Safety information for TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

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