Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listTERBUTALINE SULFATE

TERBUTALINE SULFATE

Synonym(s):2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol;5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt;Terbutaline hemisulfate salt

  • CAS NO.:23031-32-5
  • Empirical Formula: C24H40N2O10S
  • Molecular Weight: 548.65
  • MDL number: MFCD00079584
  • EINECS: 245-386-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-13 12:20:35
TERBUTALINE SULFATE Structural

What is TERBUTALINE SULFATE?

Description

Terbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp

Description

Terbutaline (hemisulfate) (Item No. 21292) is an analytical reference standard categorized as a β2-adrenergic receptor agonist. Terbutaline has been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

Chemical properties

White or almost white, crystalline powder.

Originator

Bricanyl,Pharma-Stern,W. Germany,1971

The Uses of TERBUTALINE SULFATE

Terbutaline Sulfate is derived from the starting material, Terbutaline Hemisulfate Salt (T109750), which is a β-adrenergic receptor agonist. A Bronchodilator; Metabolite of Terbutaline (T109763).

The Uses of TERBUTALINE SULFATE

A B-Adrenergic receptor agonist. A Bronchodilator

The Uses of TERBUTALINE SULFATE

betaadrenergic agonist, bronchodilator

The Uses of TERBUTALINE SULFATE

Anti Asthmatic

What are the applications of Application

Terbutaline Hemisulfate Salt is a β-adrenergic receptor agonist

What are the applications of Application

Terbutaline Hemisulfate is an agonist at β2-adrenergic receptors

Definition

ChEBI: Terbutaline sulfate is an ethanolamine sulfate salt. It is functionally related to a terbutaline.

Manufacturing Process

To a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-?-bromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-tbutylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-?-(benzyl-tbutylamino)- acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation.
15 g of 3,5-dibenzyloxy-?-(benzyl-t-butylamino)-acetophenone hydrogen sulfate in 200 ml of glacial acetic acid were hydrogenated in a Parr pressure reaction apparatus in the presence of 1.5 g of 10% palladium charcoal at 50°C and 5 atmospheres pressure. The reaction time was 5 hours. The catalyst was filtered off, the filtrate was evaporated to dryness and the hydrogen sulfate of 1-(3',5'-dihydroxyphenyl)-2-(t-butylamino)-ethanol was received. This compound is hygroscopic, but it can be transformed into a nonhygroscopic sulfate in the following manner.
The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhlet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3',5'-dihydroxyphenyl)- 2-(t-butylamino)-ethanol crystallized. Melting point 246°C to 248°C.

brand name

Terbutaline is INN and BAN.

Therapeutic Function

Bronchodilator

Clinical Use

Beta2 -adrenoceptor agonist:
Reversible airways obstruction

Veterinary Drugs and Treatments

Terbutaline is used as a bronchodilating agent in the adjunctive treatment of cardiopulmonary diseases (including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis) in small animals. It may be of some benefit in treating bradyarrhythmias in dogs and cats.
Terbutaline has been used occasionally in horses for its bronchodilating effects, but adverse effects, short duration of activity after IV administration and poor oral absorption have limited its use. It has been shown to be useful as a diagnostic agent to diagnose anhidrosis in horses after intradermal injection.
Oral and intravenous terbutaline has been used successfully in humans for the inhibition of premature labor clinical signs.

Drug interactions

Potentially hazardous interactions with other drugs
Effect may be diminished by beta-blockers.
Theophylline: increased risk of hypokalaemia.

Metabolism

Terbutaline undergoes extensive first-pass metabolism by sulphate (and some glucuronide) conjugation in the liver and the gut wall. It is excreted in the urine and faeces partly as the inactive sulphate conjugate and partly as unchanged terbutaline, the ratio depending upon the route by which it is given.

Properties of TERBUTALINE SULFATE

Melting point: 246-248°C
Density  1.1840 (rough estimate)
refractive index  1.6900 (estimate)
storage temp.  2-8°C
solubility  H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
form  neat
pka pKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
form  Solid
color  White to Off-White
InChI InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

Safety information for TERBUTALINE SULFATE

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H361:Reproductive toxicity
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for TERBUTALINE SULFATE

InChIKey KFVSLSTULZVNPG-UHFFFAOYSA-N
SMILES C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.S(=O)(=O)(O)O

Abamectin manufacturer

Brundavan Laboratories Pvt Ltd

1Y
Phone:+917095781199
Whatsapp: +91 7095781199
product: Terbutaline Sulphate 99%
Inquiry

MELODY HEALTHCARE PVT LTD

1Y
Phone:+91-2228780912
product: 23031-32-5 Terbutaline sulfate 98%
Inquiry

Souvin Pharmaceuticals Pvt Ltd

1Y
Phone:+91-8983015895
Whatsapp: +91-8983015895
product: 23031-32-5 98%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: Terbutaline sulfate 98%
Inquiry

Lanz Labs Pvt Ltd

1Y
Phone:+91-2226205525
product: Terbutaline sulfate 23031-32-5 98%
Inquiry

Anuja Healthcare Ltd

1Y
Phone:+91-9815004047
Whatsapp: +91 9815004047
product: 23031-32-5 Terbutaline sulfate 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 23031-32-5 98%
Inquiry

Jayco Chemical Industries

1Y
Phone:+91-2228458881
product: Terbutaline sulfate 99%
Inquiry

Shimoga Chemicals

1Y
Phone:+91-9423565743
Whatsapp: +91-9423565743
product: 23031-32-5 Terbutaline sulfate 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.