TCID

CAS NO.：30675-13-9
Empirical Formula: C9H2Cl4O2
Molecular Weight: 283.92
MDL number: MFCD00239209
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is TCID?

Description

TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.

The Uses of TCID

TCID is a small molecule inhibitor of DNA polymerase λ.

What are the applications of Application

UCH-L3 Inhibitor is a 1,3-indanedione compound

storage

Store at -20°C

References

1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022

Properties of TCID

Melting point:	218-220
Boiling point:	448.1±45.0 °C(Predicted)
Density	1.782±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	Soluble in DMSO (up to 25 mg/ml),
form	Orange solid
pka	8.62±0.20(Predicted)
color	White
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for TCID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.