TCID
- CAS NO.：30675-13-9
- Empirical Formula: C9H2Cl4O2
- Molecular Weight: 283.92
- MDL number: MFCD00239209
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is TCID?
Description
TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.
The Uses of TCID
TCID is a small molecule inhibitor of DNA polymerase λ.
What are the applications of Application
UCH-L3 Inhibitor is a 1,3-indanedione compound
storage
Store at -20°C
References
1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022
Properties of TCID
| Melting point: | 218-220 |
| Boiling point: | 448.1±45.0 °C(Predicted) |
| Density | 1.782±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 25 mg/ml), |
| form | Orange solid |
| pka | 8.62±0.20(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for TCID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TCID
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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