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HomeProduct name listTalampicillin hydrochloride

Talampicillin hydrochloride

  • CAS NO.:39878-70-1
  • Empirical Formula: C24H23N3O6S.ClH
  • Molecular Weight: 517.988
  • MDL number: MFCD01682149
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Talampicillin hydrochloride Structural

What is Talampicillin hydrochloride?

Description

Talampicillin was synthesized by Yamanouchi Pharmaceutical Co. in 1971 by esterifying the carboxylic acid group of ampicillin in order to improve the oral absorption. When administered orally, it is hydrolyzed to ampicillin by intestinal esterase. Its bioavailability is two or more times as high as that of ampicillin, and it is used to treat the same infections as those for which ampicillin is used orally but in doses only half or one-third as large.

Originator

Talpen,Beecham,US,1975

Manufacturing Process

A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours. After filtration the organic layer was washed twice with 250 ml portions of 1 N sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. Addition of ether crystallized the phthalide enamine protected α-aminophenylacetamido penicillanate in 85% yield.

Therapeutic Function

Antibacterial

Properties of Talampicillin hydrochloride

Melting point: 154-157° (dec)
form  neat

Safety information for Talampicillin hydrochloride

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Talampicillin hydrochloride

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