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HomeProduct name listsulforidazine

sulforidazine

sulforidazine  Structural

What is sulforidazine ?

Chemical properties

Thick Yellow Oil

Originator

Sulforidazine,ZYF Pharm Chemical

The Uses of sulforidazine

A major metabolite of Thioridazine (THD 2-SO2).

The Uses of sulforidazine

Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).

What are the applications of Application

Thioridazine 2-Sulfone is a major metabolite of Thioridazine

Definition

ChEBI: Sulforidazine is a member of phenothiazines.

Manufacturing Process

A mixture of 96.5 g 2-methylsulfonylphenothiazine, 50 g 2-(2-chloroethyl)-1- methylpiperidine, 62 g diethyl carbonate and 2 g sodium methylate was heated at 135°C for 1 hour and then at 180-190°C for 2.5 hours. The product was dissolved in benzene (500 ml) and the solution was extracted with 700 ml of 15% aqueous solution tartaric acid. The extract was washed with benzene. After addition of sodium carbonate solution to the extract was obtained a precipitate which was dissolved in benzene. This solution was washed with water and concentrated. 2-Methylsulfonyl-10-(2-(1-methyl-2- piperidyl)ethyl)phenothiazin was recrystallized from acetone, melting point 121-123°C.

Therapeutic Function

Neuroleptic

Properties of sulforidazine

Melting point: 121-123°
Boiling point: 589.1±50.0 °C(Predicted)
Density  1?+-.0.06 g/cm3(Predicted)
storage temp.  Refrigerator, Under Inert Atmosphere
solubility  Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 9.83±0.10(Predicted)
color  Off-White to Dark Yellow

Safety information for sulforidazine

Computed Descriptors for sulforidazine

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