SUGAMMADEX
- CAS NO.:343306-71-8
- Empirical Formula: C72H112O48S8
- Molecular Weight: 2002.15
- EINECS: 253-874-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:00
What is SUGAMMADEX?
Absorption
Sugammadex is administered intravenously.
Toxicity
Patients with severe renal impairment (with creatinine clearance below 30 mL/min) should avoid use of drug as their clearance of the drug is reduced and there is inconsistent evidence about its safety in this subset of patients.
Description
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
The Uses of SUGAMMADEX
6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin, also known as Sugammadex, is used to reverse postoperative residual neuromuscular blockade.
Indications
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Metabolism
No metabolites of sugammadex were observed during clinical studies.
Properties of SUGAMMADEX
Melting point: | >208°C (dec.) |
Density | 1.559±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Aqueous Acid (Slightly), Water (Slightly, Sonicated) |
form | Solid |
color | White to Pale Beige |
Safety information for SUGAMMADEX
Computed Descriptors for SUGAMMADEX
Abamectin manufacturer
ALMELO PRIVATE LIMITED
Dr. Reddy's Laboratories Ltd
Honour Lab Limited
SMS Lifesciences India Ltd (MAHI Drugs Pvt Ltd)
ASolution Pharmaceuticals Pvt Ltd
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 3-NITRO-5-ACETYL IMINODIBENZYL 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
343306-71-8 SugaMMadex SodiuM 98%View Details
343306-71-8 -
343306-71-8 98%View Details
343306-71-8 -
Sugammadex 98%View Details
-
Sugammadex 343306-71-8 98%View Details
343306-71-8 -
343306-71-8 Sugammadex 98%View Details
343306-71-8 -
343306-71-8 98%View Details
343306-71-8 -
343306-71-8 98%View Details
343306-71-8 -
acid blue 113, acid navy blue , wool navy blue 0View Details
3351-05-1