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HomeProduct name listSTACHYDRINE HYDROCHLORIDE

STACHYDRINE HYDROCHLORIDE

  • CAS NO.:4136-37-2
  • Empirical Formula: C7H14ClNO2
  • Molecular Weight: 179.64
  • MDL number: MFCD21609192
  • EINECS: 223-957-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-21 15:02:05
STACHYDRINE HYDROCHLORIDE Structural

What is STACHYDRINE HYDROCHLORIDE?

The Uses of STACHYDRINE HYDROCHLORIDE

Stachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis.

What are the applications of Application

Stachydrine Hydrochloride is a potentially useful alkaloid for activity screening and an anticancer agent in vitro

Biological Activity

stachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits.

in vitro

the aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1].

in vivo

previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].

References

[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).
[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54.

Properties of STACHYDRINE HYDROCHLORIDE

Melting point: 225°C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Methanol (Slightly), Water (Slightly)
form  Solid
color  White to Off-White
Water Solubility  Soluble in water
Merck  14,8771
Stability: Hygroscopic
CAS DataBase Reference 4136-37-2(CAS DataBase Reference)

Safety information for STACHYDRINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for STACHYDRINE HYDROCHLORIDE

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