Squalane

Synonym(s):Squalane;2,6,10,15,19,23-Hexamethyltetracosane;Perhydrosqualene;Robane;Cosbiol

CAS NO.：111-01-3
Empirical Formula: C30H62
Molecular Weight: 422.81
MDL number: MFCD00008953
EINECS: 203-825-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is Squalane?

Chemical properties

viscous colourless liquid

The Uses of Squalane

Squalane has been used: as solvent in the synthesis of Europium dibenzoylmethide triethylammonium, brightest known triboluminescent (TL) material;as lubricant for fatty acid surfactant films adsorbed on iron oxide surfaces

The Uses of Squalane

health foods

The Uses of Squalane

Lubricant, transformer oil. Ingredient of watch and chronometer oils. Perfume fixative. In pharmacy and cosmetics as skin lubricant, ingredient of suppositories, carrier of lipid-soluble drugs.

The Uses of Squalane

squalane is an excellent moisturizer and lubricant, it softens and smoothes the skin while also replenishing skin lipids. Its compatibility with skin lipids can be attributed to the fact that human sebum is made up of 25 percent squalane. Squalane has traditionally been obtained by hydrogenation of shark liver oil or other natural oils. Components found in fish oils may reduce skin irritation and allergic responses. It can also be derived from plant sources or synthetically manufactured.

Definition

A saturated hydrocarbon.

General Description

Dielectrophoretic deformation of thin liquid fillm of squalane has been investigated. Microfluidized squalenes are efficient adjuvants, eliciting both humoral and cellular immune responses.

Purification Methods

Purify squalane by fractional distillation in vacuo or evaporative distillation. It is soluble in pet ether, *C6H6, Et2O and CHCl3, slightly soluble in alcohols, Me2CO and AcOH but insoluble in H2O. Small quantities can be purified by TLC as for squalene below. It is used as a marker in GLC and HPLC. [Staudinger & Leupold Helv Chim Acta 15 223 1932, Sax & Stross Anal Chem 29 1700 1951, Mandai et al. Tetrahedron Lett 22 763 1981, Beilstein 1 IV 593.]

Properties of Squalane

Melting point:	-38 °C (lit.)
Boiling point:	176 °C/0.05 mmHg (lit.)
Density	0.81 g/mL at 25 °C (lit.)
refractive index	n20/D 1.452(lit.)
Flash point:	424 °F
storage temp.	2-8°C
solubility	chloroform: soluble100mg/mL, clear
form	neat
color	Clear Colourless
Water Solubility	Not miscible or difficult to mix in water.
Merck	14,8767
BRN	776019
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	111-01-3(CAS DataBase Reference)
NIST Chemistry Reference	Tetracosane, 2,6,10,15,19,23-hexamethyl-(111-01-3)
EPA Substance Registry System	Squalane (111-01-3)

Safety information for Squalane

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.