SPQ
- CAS NO.：83907-40-8
- Empirical Formula: C13H15NO4S
- Molecular Weight: 281.33
- MDL number: MFCD00037592
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is SPQ?
Description
SPQ is a fluorescent chloride indicator. Its fluorescence is rapidly quenched by chloride in vitro. It has been used to assess voltage-sensitive chloride transport in placental microvillus vesicles. It has also been used to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin , and phorbol 12-myristate 13-acetate (PMA; ) in isolated human erythrocytes. In addition, SPQ has been used to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2. SPQ displays excitation maxima of 320 and 350 nm and an emission maximum of 445 nm.
Chemical properties
Off-White to Tan Cyrstalline Solid
The Uses of SPQ
SPQ offers a simple and yet powerful method to examine and measure membrane chloride transport mechanisms.
What are the applications of Application
6-Methoxy-N-(3-sulfopropyl)quinolinium is a method to examine and measure membrane chloride transport mechanisms
Properties of SPQ
| Melting point: | 299°C dec. |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in water, dimethyl sulfoxide |
| form | powder |
| color | White |
| λmax | 344 nm |
| Biological Applications | Chloride indicator; nitrite indicator; diagnosis of diseases caused by elemental imbalances; detecting cancer cells,spores,stress biomarkers; identifying genes; studying chloride–bicarbonate exchange |
Safety information for SPQ
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P362:Take off contaminated clothing and wash before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for SPQ
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