SINOMENINE HYDROCHLORIDE
Synonym(s):(9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one hydrochloride;Cucoline hydrochloride;Kukolin hydrochloride
- CAS NO.:6080-33-7
- Empirical Formula: C19H23NO4.ClH
- Molecular Weight: 365.85
- MDL number: MFCD01714307
- EINECS: 618-347-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is SINOMENINE HYDROCHLORIDE?
Description
Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-
Chemical properties
White Solid
The Uses of SINOMENINE HYDROCHLORIDE
Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.
What are the applications of Application
Sinomenine hydrochloride is a natural anti-inflammatory morphinan analog
Purification Methods
Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]
Properties of SINOMENINE HYDROCHLORIDE
Melting point: | 231.0 to 235.0 °C |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: soluble20mg/mL, clear |
form | powder |
color | white to beige |
optical activity | [α]/D -70 to -90°, c = 1 in H2O |
Water Solubility | Soluble to 100 mM in water |
Safety information for SINOMENINE HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for SINOMENINE HYDROCHLORIDE
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