SINEFUNGIN
Synonym(s):sf;Foxp3;JM2;Mast Cell Growth Factor (MGF);scurfin
- CAS NO.:58944-73-3
- Empirical Formula: C15H23N7O5
- Molecular Weight: 381.39
- MDL number: MFCD00865623
- EINECS: 637-385-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is SINEFUNGIN?
Description
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5
The Uses of SINEFUNGIN
Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.
The Uses of SINEFUNGIN
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
What are the applications of Application
Sinefungin is a SAM analog and Dnmt inhibitor
Definition
ChEBI: An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
General Description
Chemical structure: nucleoside
Biochem/physiol Actions
Probable transcription factor. Plays a critical role in the control of immune response.
References
1) Barbes?et al. (1990),?Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;? FEMS Microbiol. Lett.,?57?239 2) Yebra?et al. (1991),?The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;? J. Antibiot. (Tokyo),?44?1141 3) Cheng?et al. (2004),?Small molecule regulators of protein arginine methyltransferases;? J. Biol. Chem.,?279?23892 4) Schluckebier?et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;? J. Mol. Biol., 265?56 5) Yadav?et al. (2014),?Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;? Biomed. Res. Int.,?2014?156987
Properties of SINEFUNGIN
Boiling point: | 783.2±70.0 °C(Predicted) |
alpha | D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water) |
Density | 1.91±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: soluble |
form | powder |
pka | pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃) |
color | white to yellow |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
Safety information for SINEFUNGIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SINEFUNGIN
New Products
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