Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listSilychristin

Silychristin

Synonym(s):(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one;silichristin;Silychristin;Silymarin II

  • CAS NO.:33889-69-9
  • Empirical Formula: C25H22O10
  • Molecular Weight: 482.44
  • MDL number: MFCD00883715
  • EINECS: 251-720-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Silychristin Structural

What is Silychristin?

Chemical properties

Silychristin is the second most abundant flavonolignan in the silymarin complex, which is usually produced by the acetone extraction of Silybum marianum (L.) Gaertn. (milk thistle) fruits. Natural silychristin is a mixture of two diastereomers (silychristin A and B, 95:5). Isosilychristin is a silychristin isomer mainly occurring in wild milk thistle. At the same time, 2,3-dehydrosilychristin is a product of its aerial oxidation detectable in silymarin preparations. In contrast, anhydrosilychristin is a dehydrated product obtained by treating silychristin with hydrochloric acid in hot ethanol[1].

The Uses of Silychristin

Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic fla vonolignan.

The Uses of Silychristin

Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic flavonolignan.

What are the applications of Application

Silychristin is an analytical standard

Definition

ChEBI: A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase.

Benefits

Like other components of the silymarin complex, silychristin has antioxidant properties. Its potential to scavenge the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical is nearly 14× higher than that of silybin (considered “the active component of silymarin”) and approximately 1.5× lower than that of its oxidized derivative 2,3-dehydrosilybin. This compound exhibited a higher antioxidant capacity than “traditional” antioxidants.
Silychristin was able to inhibit α-glucosidase, exhibiting a potential in the treatment of diabetes mellitus type II. Furthermore, it increased insulin secretion and decreased glucose content in induced type I diabetic rats and Mesocestoides vogae larvae.
Silychristin also displayed concentration-dependent anti-inflammatory activity and inhibited collagenase much more efficiently than its standard inhibitor 1,10-phenanthroline, thus showing a potential application in cosmeceuticals. In a transdermal study, silychristin penetrated the human skin but did not reach the basolateral side. Both acute cytotoxic and genotoxic doses were higher than 100 μM for blood platelets, peripheral blood mononuclear cells, and alveolar basal epithelial cells. Moreover, at these concentrations, this compound protected mitochondria against spontaneous DNA damage. Moreover, copper and iron chelation was also affected by silychristin, which could have implications for the absorption of these ions in the gastrointestinal tract[1].

in vitro

Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells.
It causes no cytotoxic for fibroblasts.
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent.
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells.

storage

Powder
-20°C 3 years
4°C 2 years
In solvent
-80°C 2 years
-20°C 1 year

References

[1] Simona Dobiasová. “Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential.” Antioxidants 9 5 (2020).

Properties of Silychristin

Melting point: 174~176℃
Boiling point: 782.0±60.0 °C(Predicted)
Density  1.578±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Acetone (Slightly), Methanol (Slightly)
form  neat
pka 7.39±0.60(Predicted)
form  Solid
color  White to Off-White
Water Solubility  practically insoluble in water
Stability: Hygroscopic

Safety information for Silychristin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for Silychristin

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.