SIB 1893
Synonym(s):[E]-2-Methyl-6-[2-phenylethenyl]pyridine
- CAS NO.：6266-99-5
- Empirical Formula: C14H13N
- Molecular Weight: 195.26
- MDL number: MFCD02262120
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is SIB 1893?
The Uses of SIB 1893
SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).
What are the applications of Application
SIB 1893 is a selective antagonist of mGluR-5
Definition
ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes.
Biological Activity
A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.
Properties of SIB 1893
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | solid |
| color | White to off-white |
Safety information for SIB 1893
Computed Descriptors for SIB 1893
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-((2-isopropoxyethoxy)methyl)phenol 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid 1,2,3,4-Tetrahydrocarbazol-4-one Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc) 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/Related products of tetrahydrofuran
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