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HomeProduct name listSevelamer carbonate

Sevelamer carbonate

  • CAS NO.:845273-93-0
  • Empirical Formula: C7H14ClNO4
  • Molecular Weight: 211.64
  • MDL number: MFCD18904375
  • EINECS: 682-521-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-12 15:22:14
Sevelamer carbonate Structural

What is Sevelamer carbonate?

Description

Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.
Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.

The Uses of Sevelamer carbonate

Control of serum phosphorus in patients with chronic kidney disease (phosphate binder).

The Uses of Sevelamer carbonate

Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders.

Properties of Sevelamer carbonate

storage temp.  Room Temperature, under inert atmosphere
solubility  <4.74mg/mL in DMSO
form  Solid
color  White to Pale Beige

Safety information for Sevelamer carbonate

Computed Descriptors for Sevelamer carbonate

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