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HomeProduct name listSENEGENIN

SENEGENIN

Synonym(s):12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;Tenuigenin

SENEGENIN Structural

What is SENEGENIN?

Description

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.

The Uses of SENEGENIN

Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Definition

ChEBI: Senegenin is a 12alpha-hydroxy steroid.

Properties of SENEGENIN

Melting point: 290-292℃
Boiling point: 674.1±55.0 °C(Predicted)
alpha  D +19° (c = 0.70 in ethanol)
Density  1.28
storage temp.  2-8°C
solubility  DMSO: soluble10mg/mL, clear
form  powder
pka 4.27±0.70(Predicted)
color  white to beige

Safety information for SENEGENIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for SENEGENIN

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