SENEGENIN
Synonym(s):12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;Tenuigenin
- CAS NO.:2469-34-3
- Empirical Formula: C30H45ClO6
- Molecular Weight: 537.13
- MDL number: MFCD00466906
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-22 11:49:44
What is SENEGENIN?
Description
Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.
The Uses of SENEGENIN
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
Definition
ChEBI: Senegenin is a 12alpha-hydroxy steroid.
Properties of SENEGENIN
Melting point: | 290-292℃ |
Boiling point: | 674.1±55.0 °C(Predicted) |
alpha | D +19° (c = 0.70 in ethanol) |
Density | 1.28 |
storage temp. | 2-8°C |
solubility | DMSO: soluble10mg/mL, clear |
form | powder |
pka | 4.27±0.70(Predicted) |
color | white to beige |
Safety information for SENEGENIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for SENEGENIN
Related products of tetrahydrofuran
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