Polygalacic acid

CAS NO.：22338-71-2
Empirical Formula: C30H48O6
Molecular Weight: 504.7
MDL number: MFCD12911690
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Polygalacic acid?

The Uses of Polygalacic acid

Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor.

Biological Activity

Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner .

in vitro

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.

RT-PCR

Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time:	24 hours
Result:	Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis

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Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time :	6 hours
Result:	Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Properties of Polygalacic acid

Melting point:	300-305 °C (sublm)
Boiling point:	638.1±55.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	4.41±0.70(Predicted)
color	White to off-white