Polygalacin D
- CAS NO.：66663-91-0
- Empirical Formula: C57H92O27
- Molecular Weight: 1209.34
- MDL number: MFCD28009141
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is Polygalacin D?
Chemical properties
White needle crystal. Soluble in water, ethanol, methanol and other solvents, insoluble in petroleum ether, chloroform, ethyl acetate.
Definition
ChEBI: Polygalacin D is a triterpenoid saponin. It has a role as a metabolite.
Biological Activity
Polygalacin D (PGD) is a bioactive compound with anticancer and antiproliferative properties isolated from Platycodon grandiflorum. It inhibits the expression of the IAP protein family, including survivin, cIAP-1 and cIAP-2 proteins, and blocks the PI3K/Akt pathway by inhibiting GSK3β, Akt phosphorylation and PI3K expression. It induces apoptosis through the PI3K/Akt pathway.
Properties of Polygalacin D
| Density | 1.54±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 12.76±0.70(Predicted) |
| color | White to off-white |
Safety information for Polygalacin D
Computed Descriptors for Polygalacin D
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