SD-208

Synonym(s):2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

CAS NO.：627536-09-8
Empirical Formula: C17H10ClFN6
Molecular Weight: 352.75
MDL number: MFCD09038685
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 21:40:10

What is SD-208?

The Uses of SD-208

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

What are the applications of Application

TGF-β RI Kinase Inhibitor V is a TGF-β signaling blocker

Biological Activity

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

storage

Store at RT

Properties of SD-208

Boiling point:	460.4±45.0 °C(Predicted)
Density	1.487
storage temp.	2-8°C
solubility	DMSO: >5mg/mL
form	powder
pka	4.56±0.26(Predicted)
color	off-white to tan

Safety information for SD-208

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.