SD-208
Synonym(s):2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine
- CAS NO.：627536-09-8
- Empirical Formula: C17H10ClFN6
- Molecular Weight: 352.75
- MDL number: MFCD09038685
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is SD-208?
The Uses of SD-208
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
What are the applications of Application
TGF-β RI Kinase Inhibitor V is a TGF-β signaling blocker
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
storage
Store at RT
Properties of SD-208
| Boiling point: | 460.4±45.0 °C(Predicted) |
| Density | 1.487 |
| storage temp. | 2-8°C |
| solubility | DMSO: >5mg/mL |
| form | powder |
| pka | 4.56±0.26(Predicted) |
| color | off-white to tan |
Safety information for SD-208
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SD-208
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole](https://img.chemicalbook.in/CAS/20180713/GIF/271576-80-8.gif)
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