SC-51322

Synonym(s):8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide

CAS NO.：146032-79-3
Empirical Formula: C22H20ClN3O4S
Molecular Weight: 457.93
MDL number: MFCD00916246
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is SC-51322?

Description

The prostaglandin E₂ (PGE₂) receptor (EP₁) is involved in triggering PGE₂-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP₁ antagonist that inhibits PGE₂ signaling in a guinea pig ileum muscle strip assay with a pA₂ value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED₅₀ value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE₂ with an EC₅₀ value of 7.75 μM.

Chemical properties

Off-White Solid

The Uses of SC-51322

A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.

What are the applications of Application

8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide is a potent and selective prostaglandin E2 antagonist

What are the applications of Application

SC 51322 is an effective EP1 prostanoid receptor antagonist

storage

Store at -20°C

Properties of SC-51322

Melting point:	112-114°C
RTECS	HQ4002000
storage temp.	Store at +4°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to off-white

Safety information for SC-51322

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.