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HomeProduct name listSC 19220

SC 19220

Synonym(s):2-Acetylhydrazide 10(11H)-carboxylic acid;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

SC 19220 Structural

What is SC 19220?

The Uses of SC 19220

SC 19220 is a selective EP1?receptor antagonist.

The Uses of SC 19220

SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

What are the applications of Application

SC 19220 is a selective EP1 receptor antagonist

Definition

ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether.

Biological Activity

Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells).

Biochem/physiol Actions

SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.

storage

Store at RT

Properties of SC 19220

Melting point: 190-191 °C (lit.)
storage temp.  Store at RT
solubility  DMSO: 10 mg/mL, soluble
form  solid
color  white

Safety information for SC 19220

Computed Descriptors for SC 19220

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