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SB242235

SB242235 Structural

What is SB242235?

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes
Cell Line: Human chondrocytes
Concentration: 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result: Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM.

Properties of SB242235

Boiling point: 568.4±60.0 °C(Predicted)
Density  1.34
storage temp.  2-8°C(protect from light)
solubility  DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form  Powder
pka 9.91±0.10(Predicted)
color  White to off-white

Safety information for SB242235

Computed Descriptors for SB242235

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