SB242235
- CAS NO.：193746-75-7
- Empirical Formula: C19H20FN5O
- Molecular Weight: 353.39
- MDL number: MFCD08690575
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is SB242235?
Biological Activity
SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.
in vitro
SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.
Western Blot Analysis
| Cell Line: | Human chondrocytes |
| Concentration: | 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM |
| Incubation Time: | < td class="col2"> 15 minutes|
| Result: | Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM. |
Properties of SB242235
| Boiling point: | 568.4±60.0 °C(Predicted) |
| Density | 1.34 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml |
| form | Powder |
| pka | 9.91±0.10(Predicted) |
| color | White to off-white |
Safety information for SB242235
Computed Descriptors for SB242235
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