Sanggenon C
- CAS NO.:80651-76-9
- Empirical Formula: C40H36O12
- Molecular Weight: 708.71
- MDL number: MFCD32004761
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Sanggenon C?
Description
Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.
The Uses of Sanggenon C
Sanggenone C is a flavanone isolated from Morus plant that showed cytotoxicity against human oral tumor cell lines (HSC-2 and HSG). Sanggenone C is also an inhibitor of protein tyrosine phosphatase 1B.
Definition
ChEBI: Sanggenon C is a diarylheptanoid.
Properties of Sanggenon C
Melting point: | > 240°C (dec.) |
Boiling point: | 995.5±65.0 °C(Predicted) |
Density | 1.512 |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | Acetone (Slightly), Methanol (Slightly) |
form | Solid |
pka | 6.61±0.60(Predicted) |
color | Yellow |
Safety information for Sanggenon C
Computed Descriptors for Sanggenon C
Related products of tetrahydrofuran
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