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HomeProduct name listSanggenon C

Sanggenon C

Sanggenon C Structural

What is Sanggenon C?

Description

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.

The Uses of Sanggenon C

Sanggenone C is a flavanone isolated from Morus plant that showed cytotoxicity against human oral tumor cell lines (HSC-2 and HSG). Sanggenone C is also an inhibitor of protein tyrosine phosphatase 1B.

Definition

ChEBI: Sanggenon C is a diarylheptanoid.

Properties of Sanggenon C

Melting point: > 240°C (dec.)
Boiling point: 995.5±65.0 °C(Predicted)
Density  1.512
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  Acetone (Slightly), Methanol (Slightly)
form  Solid
pka 6.61±0.60(Predicted)
color  Yellow

Safety information for Sanggenon C

Computed Descriptors for Sanggenon C

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