Salidroside

Synonym(s):p-Hydroxyphenethyl glucopyranoside;2-(4-Hydroxyphenyl)ethyl β−D-glucopyranoside;Rhodioloside;Rhodosin;Tyrosol a-(β-D-glucopyranoside)

CAS NO.：10338-51-9
Empirical Formula: C14H20O7
Molecular Weight: 300.3
MDL number: MFCD00210553
EINECS: 695-621-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is Salidroside?

Chemical properties

White to off-white solid

The Uses of Salidroside

Salidroside is a phenylpropanoid glycoside that exhibits a wide range of pharmacological effects. This include protective effects against neuronal death which can be applied to the treatment of Alzheimer’s disease. Cardioprotecticve, countering oxidative stress in cardiac related malignanied=v

Definition

ChEBI: Salidroside is a glycoside.

Benefits

Salidroside is the main active ingredient extracted from Rhodiola rosea and has antioxidant, anti-inflammatory, neuroprotective activities, activation of tumour suppressor kinases and other activities. It can be used in the treatment of neurological disorders (e.g. Alzheimer's disease, Parkinson's disease, traumatic brain injury, stroke, depression), cardiovascular diseases, tumours and other diseases. It is also used in the treatment of ulcerative colitis. In innate immunity, upregulated TREM1 pyroptosis-related proteins in inflamed colons were inhibited by salidroside administration further experiments in vitro showed that salidroside suppressed LPS/ATP-induced bone marrow-derived macrophages (BMDMs) pyroptosis evident by decline LDH IL-1β release as well as protein level NLRP3, caspase-1, GSDMD p30.

Mechanism of action

The salidroside present in R. rosea exerts its antistress, adaptogenic, and anti-depressive activity through stimulation of neuropeptide-Y with concomitant lower levels of HSP-72 (heat shock protein) release in brain microglial cells, ultimately modulating the HPA axis stress response. Salidroside could restore the balance of Th17/Treg cells, disrupted upon exposure to ischemia, thereby maintaining the peripheral neuron's stability after ischemia. Another neuroprotection mechanism by salidroside is maintaining monoamine neurotransmitters in the dopaminergic system. Monoamine oxidase (MAO) is an enzyme rich in the striatum and hypothalamus that could catalyze the oxidation of monoamines, such as dopamine, serotonin, adrenaline, non-adrenaline, and histamine[1-2].

References

[1] Mukherjee, Dhrubojyoti . "Role of Stress in Diseases and Its Remedial Approach by Herbal and Natural Products in Stress-Related Disease Management." 2018.
[2] Jingxuan Han. "Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases." Frontiers in Pharmacology (2022): 974775.

Properties of Salidroside

Melting point:	159～160℃
Boiling point:	549.5±50.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Methanol (Slightly), Pyridine (Slightly)
form	neat
pka	9.98±0.15(Predicted)
form	Solid
color	Off-White
optical activity	[α]/D -29±2°, c = 0.5 in methanol
InChI	InChI=1/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/s3
CAS DataBase Reference	10338-51-9(CAS DataBase Reference)

Safety information for Salidroside

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.