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HomeProduct name list(S)-(-)-PROPRANOLOL HYDROCHLORIDE

(S)-(-)-PROPRANOLOL HYDROCHLORIDE

Synonym(s):(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

  • CAS NO.:4199-10-4
  • Empirical Formula: C16H22ClNO2
  • Molecular Weight: 295.8
  • MDL number: MFCD00064547
  • EINECS: 224-096-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-01 17:24:36
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Structural

What is (S)-(-)-PROPRANOLOL HYDROCHLORIDE?

Description

(S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.

Chemical properties

(S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

The Uses of (S)-(-)-PROPRANOLOL HYDROCHLORIDE

The S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

The Uses of (S)-(-)-PROPRANOLOL HYDROCHLORIDE

Antihypertensor;Beta-adrenergic blocking agent

The Uses of (S)-(-)-PROPRANOLOL HYDROCHLORIDE

active enantiomer, 5-HT1 receptor antagonist

What are the applications of Application

S(?)-Propranolol hydrochloride is a β-adrenergic receptor antagonist

Biological Activity

More active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ).

Biochem/physiol Actions

(S)-(?)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(?)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.

storage

Store at RT

Purification Methods

The (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.]

Properties of (S)-(-)-PROPRANOLOL HYDROCHLORIDE

Melting point: 193-195 °C(lit.)
storage temp.  2-8°C
solubility  ethanol: 10 mg/mL
form  powder
color  White to off-white
optical activity [α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Water Solubility  Soluble to 100 mM in water
BRN  3574966
CAS DataBase Reference 4199-10-4(CAS DataBase Reference)

Safety information for (S)-(-)-PROPRANOLOL HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for (S)-(-)-PROPRANOLOL HYDROCHLORIDE

InChIKey ZMRUPTIKESYGQW-UQKRIMTDSA-N

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