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HomeProduct name listEsomeprazole magnesium dihydrate

Esomeprazole magnesium dihydrate

Synonym(s):(S)-Omeprazole magnesium hydrate;(T-4)-Bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-Magnesium hydrate;Nexium hydrate

  • CAS NO.:217087-10-0
  • Empirical Formula: C34H36MgN6O6S2.2H2O
  • Molecular Weight: 749.161
  • MDL number: MFCD11045290
  • EINECS: 633-657-2
  • Update Date: 2024-03-16 07:03:48
Esomeprazole magnesium dihydrate Structural

What is Esomeprazole magnesium dihydrate?

Use

Esomeprazole magnesium dihydrate is a proton pump inhibitor.

Mechanism of action

Esomeprazole magnesium dihydrate exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus.

Side Effects

Most common adverse reactions: ? Adults (≥ 18 years) (incidence > 1%) are headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth ? Pediatric (1 to 17 years) (incidence > 2%) are headache, diarrhea, abdominal pain, nausea, and somnolence ? Pediatric (1 month to less than 1 year) (incidence 1%) are abdominal pain, regurgitation, tachypnea, and increased ALT.

Properties of Esomeprazole magnesium dihydrate

storage temp.  2-8°C
form  neat

Safety information for Esomeprazole magnesium dihydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for Esomeprazole magnesium dihydrate

InChIKey DBOUSUONOXEWHU-VCKZSRROSA-N

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