Esomeprazole magnesium
Synonym(s):(S)-Omeprazole magnesium trihydrate;5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl] sulfinyl} benzimidazole magnesium trihydrate
- CAS NO.：161973-10-0
- Empirical Formula: C34H36MgN6O6S2
- Molecular Weight: 713.12
- EINECS: 627-029-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-15 22:11:33
What is Esomeprazole magnesium?
The Uses of Esomeprazole magnesium
Antiulcerative
The Uses of Esomeprazole magnesium
S-Form of Omeprazole. Gastric proton-pump inhibitor.
Definition
ChEBI: A magnesium salt resulting from the formal reaction of magnesium hydroxide with 2 mol eq. of esomeprazole. An inhibitor of gastric acid secretion, it is used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zolli ger-Ellison syndrome.
brand name
Nexium (AstraZeneca).
General Description
Esomeprazole magnesium,S-bis(5-rnethoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-l-yl) magnesiumtrihydrate (Nexium), is the S-enantiomer ofomeprazole. The benzimidazole PPIs contain a chiral sulfuratom that form an enantiomeric pair that is stable andinsoluble under standard conditions. The S-isomer ofomeprazole has slightly greater PPI activity, and its intrinsicclearance is approximately three times lower thanthat of R-omeprazole (15 vs. 43μL/min). The lowerclearance of S-omeprazole is related to slower metabolicclearance by the CYP2C19 isozyme. Although Romeprazoleis primarily transformed to the 5-hydroxymetabolite, the S-isomer is metabolized by O-demethylationand sulfoxidation, which contribute little to intrinsicclearance.
Properties of Esomeprazole magnesium
| Melting point: | >169°C (dec.) |
| alpha | D20 -128.2° (c = 1 in methanol) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Beige |
| Stability: | Hygroscopic |
Safety information for Esomeprazole magnesium
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Esomeprazole magnesium
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