S-NITROSOGLUTATHIONE
Synonym(s):GSNO;GSNO, SNOG;S-Nitrosoglutathione - CAS 57564-91-7 - Calbiochem;SNOG
- CAS NO.:57564-91-7
- Empirical Formula: C10H16N4O7S
- Molecular Weight: 336.32
- MDL number: MFCD00214341
- EINECS: 637-341-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is S-NITROSOGLUTATHIONE?
Description
S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.
Chemical properties
Pink Powder
The Uses of S-NITROSOGLUTATHIONE
S-Nitrosoglutathione (GSNO) has been used:
- as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
- as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.
The Uses of S-NITROSOGLUTATHIONE
A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation
What are the applications of Application
S-Nitrosoglutathione (GSNO) is a spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation
Definition
ChEBI: S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a platelet aggregation inhibitor, a bronchodilator agent, a nitric oxide donor and a signalling molecule. It is a glutathione derivative and a nitrosothio compound. It is a conjugate acid of a S-nitrosoglutathione(2-).
General Description
A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.
Biological Activity
A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.
Biochem/physiol Actions
Product does not compete with ATP.
storage
Desiccate at -20°C
Properties of S-NITROSOGLUTATHIONE
Melting point: | >170°C (dec.) |
Density | 1.68 |
refractive index | 1.6000 (estimate) |
storage temp. | -20°C |
solubility | DMSO (Slightly), Water (Slightly) |
form | Pink solid |
pka | 2.21±0.10(Predicted) |
color | Off-White to Pink |
Water Solubility | Soluble to 100 mM in water |
Stability: | Hygroscopic |
CAS DataBase Reference | 57564-91-7(CAS DataBase Reference) |
Safety information for S-NITROSOGLUTATHIONE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for S-NITROSOGLUTATHIONE
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