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HomeProduct name listS-NITROSOGLUTATHIONE

S-NITROSOGLUTATHIONE

Synonym(s):GSNO;GSNO, SNOG;S-Nitrosoglutathione - CAS 57564-91-7 - Calbiochem;SNOG

  • CAS NO.:57564-91-7
  • Empirical Formula: C10H16N4O7S
  • Molecular Weight: 336.32
  • MDL number: MFCD00214341
  • EINECS: 637-341-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
S-NITROSOGLUTATHIONE Structural

What is S-NITROSOGLUTATHIONE?

Description

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.

Chemical properties

Pink Powder

The Uses of S-NITROSOGLUTATHIONE

S-Nitrosoglutathione (GSNO) has been used:

  • as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD).
  • as a standard in spectrophotometric and high-performance liquid chromatography (HPLC) assay.

The Uses of S-NITROSOGLUTATHIONE

A carrier of nitric oxide, relaxing smooth muscle and inhibiting platelet activation

What are the applications of Application

S-Nitrosoglutathione (GSNO) is a spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation

Definition

ChEBI: S-nitrosoglutathione is a glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group. It has a role as a platelet aggregation inhibitor, a bronchodilator agent, a nitric oxide donor and a signalling molecule. It is a glutathione derivative and a nitrosothio compound. It is a conjugate acid of a S-nitrosoglutathione(2-).

General Description

A utility carrier of nitric oxide. Breaks down at physiological pH to produce nitric oxide. Causes smooth muscle relaxation and inhibits platelet aggregation. Induces apoptosis in mouse thymocytes. Note: 1 set = 5 x 2.5 mg.

Biological Activity

A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.

Biochem/physiol Actions

Product does not compete with ATP.

storage

Desiccate at -20°C

Properties of S-NITROSOGLUTATHIONE

Melting point: >170°C (dec.)
Density  1.68
refractive index  1.6000 (estimate)
storage temp.  -20°C
solubility  DMSO (Slightly), Water (Slightly)
form  Pink solid
pka 2.21±0.10(Predicted)
color  Off-White to Pink
Water Solubility  Soluble to 100 mM in water
Stability: Hygroscopic
CAS DataBase Reference 57564-91-7(CAS DataBase Reference)

Safety information for S-NITROSOGLUTATHIONE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H311:Acute toxicity,dermal
H331:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P330:Rinse mouth.
P361:Remove/Take off immediately all contaminated clothing.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.
P501:Dispose of contents/container to..…

Computed Descriptors for S-NITROSOGLUTATHIONE

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