NOC-18
Synonym(s):DETA NONOate;NOC-18;DETA/NO, 2,2?-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate;DETA/NO, 2,2?-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate;2,2′-(Hydroxynitrosohydrazino)bis-ethanamine
- CAS NO.:146724-94-9
- Empirical Formula: C4H13N5O2
- Molecular Weight: 163.18
- MDL number: MFCD00278808
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:06
What is NOC-18?
Description
DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
Chemical properties
White Powder
The Uses of NOC-18
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.
The Uses of NOC-18
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.
What are the applications of Application
NOC-18 is a diazeniumdiolate slow-releasing NO donor
Definition
ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Biochem/physiol Actions
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.
References
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
Properties of NOC-18
Melting point: | 98-106 °C |
Boiling point: | 290.26°C (rough estimate) |
Density | 1.3102 (rough estimate) |
refractive index | 1.8000 (estimate) |
storage temp. | -20°C |
solubility | H2O: >20 mg/mL |
form | solid |
pka | 4.50±0.69(Predicted) |
color | off-white |
Stability: | Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored. |
CAS DataBase Reference | 146724-94-9 |
Safety information for NOC-18
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 |
GHS Hazard Statements |
H242:Self-reactive substances and mixtures; and Organic peroxides |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P235:Keep cool. P240:Ground/bond container and receiving equipment. P370+P378:In case of fire: Use … for extinction. P403:Store in a well-ventilated place. |
Computed Descriptors for NOC-18
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