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HomeProduct name listNOC-18

NOC-18

Synonym(s):DETA NONOate;NOC-18;DETA/NO, 2,2?-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate;DETA/NO, 2,2?-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate;2,2′-(Hydroxynitrosohydrazino)bis-ethanamine

NOC-18 Structural

What is NOC-18?

Description

DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.

Chemical properties

White Powder

The Uses of NOC-18

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.

The Uses of NOC-18

A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.

Definition

ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.

What are the applications of Application

NOC-18 is a diazeniumdiolate slow-releasing NO donor

Biochem/physiol Actions

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.

References

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281

Properties of NOC-18

Melting point: 98-106 °C
Boiling point: 290.26°C (rough estimate)
Density  1.3102 (rough estimate)
refractive index  1.8000 (estimate)
storage temp.  -20°C
solubility  H2O: >20 mg/mL
form  solid
pka 4.50±0.69(Predicted)
color  off-white
Stability: Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
CAS DataBase Reference 146724-94-9

Safety information for NOC-18

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
GHS Hazard Statements H242:Self-reactive substances and mixtures; and Organic peroxides
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234:Keep only in original container.
P235:Keep cool.
P240:Ground/bond container and receiving equipment.
P370+P378:In case of fire: Use … for extinction.
P403:Store in a well-ventilated place.

Computed Descriptors for NOC-18

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