(S)-(+)-Epichlorohydrin
Synonym(s):(S)-(+)-2-(Chloromethyl)oxirane;1-Chloro-2,3-epoxypropane, 2-Chloromethyl oxirane, 2,3-Epoxypropyl chloride;Epichlorohydrine
- CAS NO.:67843-74-7
- Empirical Formula: C3H5ClO
- Molecular Weight: 92.52
- MDL number: MFCD00077760
- EINECS: 614-150-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
![(S)-(+)-Epichlorohydrin Structural](https://img.chemicalbook.in/CAS/GIF/67843-74-7.gif)
What is (S)-(+)-Epichlorohydrin?
Chemical properties
Epichlorhydrin is a colourless liquid with odour, b.p. 115°C.
The Uses of (S)-(+)-Epichlorohydrin
(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.
The Uses of (S)-(+)-Epichlorohydrin
S-enantiomer of Epichlorohydrin, (S)-Epichlorohydrin), an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.
Definition
ChEBI: (S)-epichlorohydrin is an epichlorohydrin. It is functionally related to a (R)-1,2-epoxypropane. It is an enantiomer of a (R)-epichlorohydrin.
Synthesis
(S)-(+)-Epichlorohydrin is a chlorohydrin that is used as an industrial chemical. It can be synthesized by reacting benzyl chloride with sodium hydroxide in the presence of water.
Properties of (S)-(+)-Epichlorohydrin
Melting point: | −57 °C(lit.) |
Boiling point: | 92-93 °C360 mm Hg(lit.) |
alpha | 34 º (589nm, c=1, MeOH) |
Density | 1.183 g/mL at 25 °C(lit.) |
vapor density | 3.2 (vs air) |
vapor pressure | 13.8 mm Hg ( 21.1 °C) |
refractive index | n |
Flash point: | 93 °F |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform, Methanol (Slightly) |
form | Liquid |
color | Clear colorless to very pale yellow |
explosive limit | 21% |
optical activity | [α]20/D +35°, c = 1 in methanol |
Water Solubility | insoluble |
BRN | 1420784 |
Dielectric constant | 22.9(20℃) |
CAS DataBase Reference | 67843-74-7(CAS DataBase Reference) |
Safety information for (S)-(+)-Epichlorohydrin
Signal word | Danger |
Pictogram(s) |
![]() Flame Flammables GHS02 ![]() Corrosion Corrosives GHS05 ![]() Skull and Crossbones Acute Toxicity GHS06 ![]() Health Hazard GHS08 |
GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation H317:Sensitisation, Skin H350:Carcinogenicity |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-(+)-Epichlorohydrin
New Products
1-Amino-1-cyclohexanecarboxylic acid Cycloleucine 6-Bromo-3-iodo-1-methyl-1H-indazole 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 7-Bromo-1H-indazole ELECTROLYTIC IRON POWDER 2-Methyl-2-phenylpropyl acetate 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride Decanonitrile tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 4-Ethylbenzylamine Methyl 5-bromo-2-chloro-3-nitrobenzoate N-(5-Amino-2-methylphenyl)acetamide 2-Chloro-3-nitropyridine 5-Bromo-2,3-dimethoxypyridine methyl 6-chloro-2-(chloromethyl)nicotinate 2-methoxy-4-methyl-5-nitro pyridine 2-iodo-5-bromo pyridine 2-amino-4-methyl-5-nitro pyridine 5-Fluoro-2-Oxindole methyl L-alaninate hydrochloride diethyl L-glutamate hydrochloride Ethyl tosylcarbamateRelated products of tetrahydrofuran
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