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HomeProduct name list(S)-CR8

(S)-CR8

Synonym(s):2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem

(S)-CR8 Structural

What is (S)-CR8?

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

What are the applications of Application

CR8, (S)-Isomer is a cell-permeable (R)-DRF053 analog

Definition

ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.

Properties of (S)-CR8

Boiling point: 671.4±65.0 °C(Predicted)
Density  1.27±0.1 g/cm3(Predicted)
storage temp.  +2C to +8C
solubility  DMSO: soluble,Ethanol: soluble
form  Off-white solid
pka 14.56±0.10(Predicted)
color  White to off-white

Safety information for (S)-CR8

Computed Descriptors for (S)-CR8

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