(S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
Synonym(s):(S)-1-(4-Nitrophenyl)ethylamine hydrochloride
- CAS NO.:132873-57-5
- Empirical Formula: C8H11ClN2O2
- Molecular Weight: 202.64
- MDL number: MFCD00066312
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:36
What is (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE?
The Uses of (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
(S)-α-Methyl-4-nitrobenzylamine hydrochloride can be used as:
- A fluorescence-quenching guest in the determination of chiral recognition capabilities of binaphthocrown ether and polythiophene complex.
- A starting material in the synthesis of chiral cyclopalladated complexes with applications in the resolution of racemic compounds.
Purification Methods
To ensure dryness, the hydrochloride (ca 175 g) is extracted with EtOH (3x100mL) and evaporated to dryness (any residual H2O increases the solubility in EtOH and lowers the yield). The hydrochloride residue is triturated with absolute EtOH and dried in vacuo. The product is further purified by refluxing with absolute EtOH (200 mL for 83g) for 1hour, and cool to 10o to give 76.6g of hydrochloride m 243-245o(dec). The free base is prepared by dissolving in N NaOH, extracting with CH2Cl2 (3 x 500mL), drying (Na2CO3), filtering, evaporating and distilling it. It has m 27o, b 119-120o/0.5mm (105-107o/0.5mm, 157-159o/9mm, d 1.1764, n 1.5688, [] ±17.7o (neat) [Perry et al. Synthesis 492 1977,ORD: Nerdel & Liebig Justus Liebigs Ann Chem 621 142 1959]. [Beilstein 12 IV 2451.]
Properties of (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
Melting point: | 248-250 °C(lit.) |
refractive index | -7.2 ° (C=1, 0.05mol/L NaOH) |
storage temp. | Inert atmosphere,Room Temperature |
form | powder to crystal |
color | White to Light yellow |
optical activity | [α]25/D 6.5°, c = 1 in 0.05 M NaOH |
Water Solubility | faint turbidity |
CAS DataBase Reference | 132873-57-5(CAS DataBase Reference) |
Safety information for (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for (S)-ALPHA-METHYL-4-NITROBENZYLAMINE HYDROCHLORIDE
New Products
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