(S)-(-)-2-Methyl-2-propanesulfinamide
- CAS NO.：343338-28-3
- Empirical Formula: C4H11NOS
- Molecular Weight: 121.2
- MDL number: MFCD05861480
- EINECS: 640-158-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 18:16:58
What is (S)-(-)-2-Methyl-2-propanesulfinamide?
Physical properties
white to light yellow crystal powder
The Uses of (S)-(-)-2-Methyl-2-propanesulfinamide
(S)-(-)-2-Methyl-2-propanesulfinamide is used in Suzuki reaction. It is also employed as a reagent for synthesizing chiral amines. It acts as a chiral auxiliary used in an asymmetric synthesis of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine. It is also involved in the transformation of P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. Further, it serves as a reagent for the preparation of chemicals and pharmaceutical intermediates.
The Uses of (S)-(-)-2-Methyl-2-propanesulfinamide
(S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents. It may also be used to prepare (20E)-N-[t-butyl-(S)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the preparation of androgen receptor antagonists.
Properties of (S)-(-)-2-Methyl-2-propanesulfinamide
| Melting point: | 97-101 °C(lit.) |
| Boiling point: | 220.0±23.0 °C(Predicted) |
| alpha | -4.5 º (c=1, CHCl3) |
| Density | 1.124 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 10.11±0.50(Predicted) |
| color | White |
| optical activity | [α]20/D 4.5°, c = 1 in chloroform |
| Stability: | store cold |
| InChI | InChI=1/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3/t7-/s3 |
| CAS DataBase Reference | 343338-28-3(CAS DataBase Reference) |
Safety information for (S)-(-)-2-Methyl-2-propanesulfinamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for (S)-(-)-2-Methyl-2-propanesulfinamide
| InChIKey | CESUXLKAADQNTB-SSDOTTSWSA-N |
| SMILES | CC(C)([S@@](N)=O)C |&1:3,r| |
(S)-(-)-2-Methyl-2-propanesulfinamide manufacturer
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