(S)-(-)-2-Chloropropionic acid
Synonym(s):(S)-(−)-2-Chloropropanoic acid;L -α-Chloropropionic acid
- CAS NO.：29617-66-1
- Empirical Formula: C3H5ClO2
- Molecular Weight: 108.52
- MDL number: MFCD00064205
- EINECS: 411-150-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is (S)-(-)-2-Chloropropionic acid?
Chemical properties
Colourless Oil
The Uses of (S)-(-)-2-Chloropropionic acid
Through the stereo displacement of (S)-(-)-2-Chloropropionic acid PPAR Agonist can be synthesized via asymmetric hydrogenation of a cinnamic acid derivative.
Definition
ChEBI: A monocarboxylic acid that is propanoic acid substitued at position 2 by a chloro group (the S-enantiomer).
Flammability and Explosibility
Non flammable
Purification Methods
Purify the acid by fractionating twice through a 115cm Podbielniak column (p 11, calculated 50 theoretical plates at atmospheric pressure) using a take-off ratio of 1:5. The acid chloride is prepared by dissolving the acid in SOCl2, adding a few drops of PCl3, refluxing and then distilling through a 30cm column, b 53o/100mm, [] -4.6o (neat), d 1.2689, n1.4368. [Fu et al. J Am Chem Soc 76 6954 1954, Beilstein 2 IV 745.]
Properties of (S)-(-)-2-Chloropropionic acid
| Melting point: | 4 °C |
| Boiling point: | 77 °C/10 mmHg (lit.) |
| alpha | -14.5 º (c=neat) |
| Density | 1.249 g/mL at 25 °C (lit.) |
| vapor pressure | 5hPa at 20℃ |
| refractive index | n |
| Flash point: | 140 °F |
| storage temp. | 2-8°C
|
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 2.83(at 25℃) |
| form | Liquid |
| color | Clear light yellow |
| Water Solubility | soluble |
| BRN | 1720257 |
| CAS DataBase Reference | 29617-66-1(CAS DataBase Reference) |
| NIST Chemistry Reference | (S)-(-)-2-chloropropionic acid(29617-66-1) |
Safety information for (S)-(-)-2-Chloropropionic acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H290:Corrosive to Metals H302:Acute toxicity,oral H312:Acute toxicity,dermal H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P501:Dispose of contents/container to..… |
Computed Descriptors for (S)-(-)-2-Chloropropionic acid
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