Rubitecan
Synonym(s):9-nitrocamptothecin
- CAS NO.：91421-42-0
- Empirical Formula: C20H15N3O6
- Molecular Weight: 393.35
- MDL number: MFCD06656294
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:14
What is Rubitecan?
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical properties
Yellow Amorphous Powder
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
What are the applications of Application
Rubitecan is a DNA topoisomerase I inhibitor
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Properties of Rubitecan
| Melting point: | 182-186°C |
| alpha | D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4) |
| Boiling point: | 816.3±65.0 °C(Predicted) |
| Density | 1.63 |
| Flash point: | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Chloroform, Methanol |
| form | Solid |
| pka | 11.16±0.20(Predicted) |
| color | Yellow |
| Merck | 14,8288 |
| CAS DataBase Reference | 91421-42-0(CAS DataBase Reference) |
Safety information for Rubitecan
Computed Descriptors for Rubitecan
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin A Tubulysin C 2,2-diethoxyethanethioamide Tubulysin F Potassium HMDS (1.0 M in THF) Diethyl Aluminium Cyanide (1.0 M in Toluene) 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 2,2-Difluoropropanol Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamateRelated products of tetrahydrofuran
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