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HomeProduct name listRubitecan

Rubitecan

Synonym(s):9-nitrocamptothecin

Rubitecan Structural

What is Rubitecan?

Description

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.

Chemical properties

Yellow Amorphous Powder

The Uses of Rubitecan

Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic

The Uses of Rubitecan

Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.

What are the applications of Application

Rubitecan is a DNA topoisomerase I inhibitor

Definition

ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

Properties of Rubitecan

Melting point: 182-186°C
alpha  D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
Boiling point: 816.3±65.0 °C(Predicted)
Density  1.63
Flash point: 106℃
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO, Chloroform, Methanol
form  Solid
pka 11.16±0.20(Predicted)
color  Yellow
Merck  14,8288
CAS DataBase Reference 91421-42-0(CAS DataBase Reference)

Safety information for Rubitecan

Computed Descriptors for Rubitecan

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