(R,S)-ANATABINE
- CAS NO.:2743-90-0
- Empirical Formula: C10H12N2
- Molecular Weight: 160.22
- MDL number: MFCD00078278
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is (R,S)-ANATABINE?
Description
(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-
Chemical properties
Light Yellow Oil
The Uses of (R,S)-ANATABINE
(R,S)-Anatabine is a metabolite of Nicotine (N412420).
The Uses of (R,S)-ANATABINE
A nicotine metabolite
The Uses of (R,S)-ANATABINE
A nicotine (N412420) metabolite.
What are the applications of Application
(R,S)-Anatabine is a nicotine metabolite
in vitro
anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].
in vivo
in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].
References
[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.
Properties of (R,S)-ANATABINE
Boiling point: | 136 |
Density | 1.045±0.06 g/cm3(Predicted) |
storage temp. | Amber Vial, Refrigerator, Under Inert Atmosphere |
solubility | ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide |
form | solution in ethanol. |
pka | 8.84±0.40(Predicted) |
color | Light yellow to yellow |
Stability: | Hygroscopic, Light Sensitive |
CAS DataBase Reference | 2743-90-0 |
Safety information for (R,S)-ANATABINE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for (R,S)-ANATABINE
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