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HomeProduct name list(R,S)-ANATABINE

(R,S)-ANATABINE

(R,S)-ANATABINE Structural

What is (R,S)-ANATABINE?

Description

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

Chemical properties

Light Yellow Oil

The Uses of (R,S)-ANATABINE

(R,S)-Anatabine is a metabolite of Nicotine (N412420).

The Uses of (R,S)-ANATABINE

A nicotine metabolite

The Uses of (R,S)-ANATABINE

A nicotine (N412420) metabolite.

What are the applications of Application

(R,S)-Anatabine is a nicotine metabolite

in vitro

anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].

in vivo

in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].

References

[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.

Properties of (R,S)-ANATABINE

Boiling point: 136
Density  1.045±0.06 g/cm3(Predicted)
storage temp.  Amber Vial, Refrigerator, Under Inert Atmosphere
solubility  ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
form  solution in ethanol.
pka 8.84±0.40(Predicted)
color  Light yellow to yellow
Stability: Hygroscopic, Light Sensitive
CAS DataBase Reference 2743-90-0

Safety information for (R,S)-ANATABINE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for (R,S)-ANATABINE

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