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HomeProduct name listNeotuberostemonine

Neotuberostemonine

  • CAS NO.:143120-46-1
  • Empirical Formula: C22H33NO4
  • Molecular Weight: 375.5
  • MDL number: MFCD17214798
  • EINECS: 200-158-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Neotuberostemonine Structural

What is Neotuberostemonine?

Description

Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages. Neotuberostemonine demonstrates antitussive properties in guinea pigs.

The Uses of Neotuberostemonine

Neotuberostemonine is a major bioactive alkaloid of Stemona tuberosa. It can also be used to treat pulmonary fibrosis.

Definition

ChEBI: Neotuberostemonine is an alkaloid. It has a role as a metabolite.

Biological Functions

Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.

Biological Activity

Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.

Properties of Neotuberostemonine

Boiling point: 554.2±50.0 °C(Predicted)
Density  1.19±0.1 g/cm3(Predicted)
solubility  DMSO: 10 mM
form  A crystalline solid
pka 8.90±0.70(Predicted)
color  White to off-white

Safety information for Neotuberostemonine

Computed Descriptors for Neotuberostemonine

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