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HomeProduct name listRosmarinic acid

Rosmarinic acid

Synonym(s):(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid;3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester;Rosmarinic acid

  • CAS NO.:20283-92-5
  • Empirical Formula: C18H16O8
  • Molecular Weight: 360.31
  • MDL number: MFCD00017740
  • EINECS: 606-487-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
Rosmarinic acid Structural

What is Rosmarinic acid?

Description

Rosmarinic acid (20283-92-5) displays radical scavenging1, anti-inflammatory2 and amyloid-β aggregation inhibition activities.3 Rosmarinic acid has also been shown to act as an agonist at GPR35.4

Description

Carnosic acid (top two images) is a diterpene with an abietane skeleton; rosmarinic acid (bottom two) is a caffeic acid ester.?Both are found in the rosemary plant (Rosmarinus officinalis), each also occurs in other plants.
But carnosic and rosmarinic acids have something else in common:?They are meat preservatives. Rosemary extract was originally added to meat as a flavoring agent, but people noticed that it kept meat from spoiling. It was later discovered that the acids inhibit the free-radical reaction that oxidizes fats and oils and causes spoilage. Neither acid is responsible for the rosemary flavor.

Chemical properties

White to off-white powder

The Uses of Rosmarinic acid

Rosmarinic Acid is a phenolic compound with antioxidant and anti-inflammatory activity. Rosmarinic Acid has been shown to inhibit againts peroxidative damage to biomembranes. Rosmarinic Acid also supp resses endotoxin-induced activation of complement and concomitant prostacyclin biosynthesis.

The Uses of Rosmarinic acid

An activator of GPR35.

The Uses of Rosmarinic acid

Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 μg/ml. Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin. Formation of 5-HETE and LTB4 from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.

What are the applications of Application

Rosmarinic Acid is an activator of GPR35

Definition

ChEBI: (R)-rosmarinic acid is a stereoisomer of rosmarinic acid having (R)-configuration. It has a role as a plant metabolite and a geroprotector. It is a conjugate acid of a (R)-rosmarinate. It is an enantiomer of a (S)-rosmarinic acid.

General Description

Rosmarinic acid is a bioactive plant phenolic compound with antioxidant and anti-inflammatory effects.

Biological Activity

Anti-inflammatory, cytostatic and antiviral.

Biochem/physiol Actions

Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and cancer chemoprevention.

Mode of action

Rosmarinic acid (RA), a water-soluble polyphenolic compound with antioxidant and anti-inflammatory properties. Inhibits several complement-dependent inflammatory processes via inhibition of the C5 convertase. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.?

References

1) Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; J. Nat. Prod., 68 168 2) Sahu et al. (1999), Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b; Biochem. Pharmacol, 57 1439 3) Ono et al. (2012), Phenolic compounds prevented amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding; J. Biol. Chem., 287 14631 4) Deng et al. (2012), Multiple tyrosine metabolites are GPR35 agonists; Sci. Rep., 2 373

Properties of Rosmarinic acid

Melting point: 171-175 °C (lit.)
Boiling point: 694.7±55.0 °C(Predicted)
alpha  +102~+110°(D/20℃)(c=0.2,C2H5OH)
Density  1.33
storage temp.  2-8°C
solubility  Soluble in ethanol, DMSO or dimethyl formamide to approximately 25 mg/mL.
form  powder
pka 2.78±0.10(Predicted)
color  white to faintly beige
BRN  2227587
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChI InChI=1/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/s3
CAS DataBase Reference 20283-92-5(CAS DataBase Reference)

Safety information for Rosmarinic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Rosmarinic acid

InChIKey DOUMFZQKYFQNTF-WUTVXBCWSA-N
SMILES C(C1C=CC(O)=C(O)C=1)[C@H](C(=O)O)OC(=O)/C=C/C1C=CC(O)=C(O)C=1 |&1:9,r|

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