Rhodanine

Chemical properties

light yellow to beige fine crystalline powder

The Uses of Rhodanine

In the case of reagents containing several potential donor atoms, one of the first steps in the study of complex formation is the specification of the functional groups which actually participate in the complexation reaction. The literature on rhodanine derivatives provides a good example of such examinations.

The Uses of Rhodanine

thiadiazole pharmaceutical intermediate

The Uses of Rhodanine

In the synthesis of phenylalanine.

Definition

ChEBI: Rhodanine is a thiazolidinone.

General Description

Light yellow crystals. Density 0.868 g / cm3. Melting point 168.5°C. May explode on rapid heating.

Air & Water Reactions

Water soluble.

Reactivity Profile

Rhodanine may generate hydrogen sulfide with acids. May generate heat and hydrogen gas with alkali metals, nitrides, hydrides, and other strong reducing agents.

Hazard

May explode when heated to 166C. Toxic by ingestion.

Biochem/physiol Actions

Rhodanine inhibits the multiplication of echovirus 12 and the development of virus-induced morphologic changes.

Purification Methods

Crystallise rhodanine from glacial acetic acid or water. It is used to estimate Ag and gallic acid [Thies & Fischer Microchimica Acta 809 1973]. [Beilstein 27 H 242, 27 I 309, 27 II 288, 27 III/IV 3188.]