Rebamipide
Synonym(s):α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate;Mucosta hydrate;OPC 12759 hydrate;Proamipide hydrate
- CAS NO.：90098-04-7
- Empirical Formula: C19H15ClN2O4
- Molecular Weight: 370.79
- MDL number: MFCD00866895
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-23 13:58:55
What is Rebamipide?
Chemical properties
White Powder
The Uses of Rebamipide
Shows antiulcer activity in rats
The Uses of Rebamipide
antiulcer, antioxidant
The Uses of Rebamipide
An inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger.
Background
Rebamipide has been investigated for the treatment of Stomach Ulcer, Keratoconjunctivitis Sicca, and Gastric Adenoma and Early Gastric Cancer.
What are the applications of Application
Rebamipide is an inducer of endogenous prostaglandin and a oxygen-derived free radical scavenger
Definition
ChEBI: 2-[[(4-chlorophenyl)-oxomethyl]amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid is a secondary carboxamide.
Biochem/physiol Actions
Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Beh?et′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.
Metabolism
Not Available
Properties of Rebamipide
| Melting point: | 288-290°C dec. |
| Boiling point: | 695.0±55.0 °C(Predicted) |
| Density | 1.394±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >5mg/mL |
| form | powder |
| pka | 3.38±0.10(Predicted) |
| color | white |
| Merck | 14,8124 |
| CAS DataBase Reference | 90098-04-7(CAS DataBase Reference) |
Safety information for Rebamipide
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Rebamipide
| InChIKey | ALLWOAVDORUJLA-UHFFFAOYSA-N |
Rebamipide manufacturer
Suma Chemicals Private Limited
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