(R)-(+)-PROPRANOLOL
Synonym(s):(R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;(R)-(+)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;(R)-(+)-Propanolol hydrochloride;Propranolol HCl
- CAS NO.:13071-11-9
- Empirical Formula: C16H21NO2.ClH
- Molecular Weight: 295.81
- MDL number: MFCD00064546
- EINECS: 235-961-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is (R)-(+)-PROPRANOLOL?
Physical properties
(R)-Propranolol's solubility:ethanol: 10 mg/mLDMSO: <14.5 mg/mLH2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
The Uses of (R)-(+)-PROPRANOLOL
The R-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
The Uses of (R)-(+)-PROPRANOLOL
less active enantiomer
What are the applications of Application
2R-(+)-Propanolol hydrochloride is the less active enantiomer of the β-adrenoceptor antagonist propranolol
Biochem/physiol Actions
Less active enantiomer of propranolol.
Mechanism of action
Pronolol hydrochloride is a non-selective beta-receptor blocker that blocks beta receptors in the myocardium and has antagonistic effects on beta1 and beta2 receptors. Slow down the heart rate, inhibit cardiac contractility and conduction, reduce circulating blood volume, and reduce myocardial oxygen consumption.
storage
Store at RT
Purification Methods
The hydrochloride is recrystallised from n-PrOH or Me2CO. It is soluble in H2O and EtOH but is insoluble in Et2O, *C6H6 or EtOAc. The racemate has m 163-164o, and the free base recrystallises from cyclohexane with m 96o. [Howe & Shanks Nature 210 1336 1966.] The S-isomer (below) is the physiologically active isomer.
Properties of (R)-(+)-PROPRANOLOL
Melting point: | 196-198 °C(lit.) |
storage temp. | Store below +30°C. |
solubility | ethanol: 10 mg/mL |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble to 100 mM in water |
BRN | 5780490 |
CAS DataBase Reference | 13071-11-9(CAS DataBase Reference) |
Safety information for (R)-(+)-PROPRANOLOL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for (R)-(+)-PROPRANOLOL
Abamectin manufacturer
Neugen Labs
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