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HomeProduct name list(R)-(+)-PROPRANOLOL

(R)-(+)-PROPRANOLOL

Synonym(s):(R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;(R)-(+)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;(R)-(+)-Propanolol hydrochloride;Propranolol HCl

  • CAS NO.:13071-11-9
  • Empirical Formula: C16H21NO2.ClH
  • Molecular Weight: 295.81
  • MDL number: MFCD00064546
  • EINECS: 235-961-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
(R)-(+)-PROPRANOLOL Structural

What is (R)-(+)-PROPRANOLOL?

Physical properties

(R)-Propranolol's solubility:ethanol: 10 mg/mLDMSO: <14.5 mg/mLH2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)

The Uses of (R)-(+)-PROPRANOLOL

The R-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

The Uses of (R)-(+)-PROPRANOLOL

less active enantiomer

What are the applications of Application

2R-(+)-Propanolol hydrochloride is the less active enantiomer of the β-adrenoceptor antagonist propranolol

Biochem/physiol Actions

Less active enantiomer of propranolol.

Mechanism of action

Pronolol hydrochloride is a non-selective beta-receptor blocker that blocks beta receptors in the myocardium and has antagonistic effects on beta1 and beta2 receptors. Slow down the heart rate, inhibit cardiac contractility and conduction, reduce circulating blood volume, and reduce myocardial oxygen consumption.

storage

Store at RT

Purification Methods

The hydrochloride is recrystallised from n-PrOH or Me2CO. It is soluble in H2O and EtOH but is insoluble in Et2O, *C6H6 or EtOAc. The racemate has m 163-164o, and the free base recrystallises from cyclohexane with m 96o. [Howe & Shanks Nature 210 1336 1966.] The S-isomer (below) is the physiologically active isomer.

Properties of (R)-(+)-PROPRANOLOL

Melting point: 196-198 °C(lit.)
storage temp.  Store below +30°C.
solubility  ethanol: 10 mg/mL
form  Solid
color  White to Off-White
Water Solubility  Soluble to 100 mM in water
BRN  5780490
CAS DataBase Reference 13071-11-9(CAS DataBase Reference)

Safety information for (R)-(+)-PROPRANOLOL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for (R)-(+)-PROPRANOLOL

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