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HomeProduct name listR(-)-DENOPAMINE

R(-)-DENOPAMINE

Synonym(s):(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxy-benzyl-alcohol

R(-)-DENOPAMINE Structural

What is R(-)-DENOPAMINE?

Description

Denopamine is a potent orally-active cardiotonic with selective effects on the beta, adrenergic receptors. Unlike isoproterenol or dobutamine, denopamine’s positive inotropic activity is not mediated through the release of catecholamines; its lack of effect on heart rate and myocardial oxygen consumption thus offers significant advantages in the management of congestive heart failure.

Originator

Tanabe Seiyaku (Japan)

The Uses of R(-)-DENOPAMINE

R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).

Definition

ChEBI: Denopamine is a dimethoxybenzene.

brand name

Kalgut

Biochem/physiol Actions

Denopamine is a cardiotonic drug.

Properties of R(-)-DENOPAMINE

Melting point: 135°C
Boiling point: 456.67°C (rough estimate)
Density  1.1949 (rough estimate)
refractive index  1.5740 (estimate)
storage temp.  2-8°C
solubility  DMSO: 26 mg/mL, soluble
form  powder
pka 9.97±0.26(Predicted)
color  white

Safety information for R(-)-DENOPAMINE

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H361:Reproductive toxicity
Precautionary Statement Codes P281:Use personal protective equipment as required.

Computed Descriptors for R(-)-DENOPAMINE

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