(R)-(-)-3-Chloro-1,2-propanediol

Synonym(s):(R)-α-Glycerol chlorohydrin

CAS NO.：57090-45-6
Empirical Formula: C3H7ClO2
Molecular Weight: 110.54
MDL number: MFCD00135169
EINECS: 611-463-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-30 16:49:16

(R)-(-)-3-Chloro-1,2-propanediol Structural

What is (R)-(-)-3-Chloro-1,2-propanediol?

Chemical properties

clear light yellow liquid

The Uses of (R)-(-)-3-Chloro-1,2-propanediol

(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.

Definition

ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol.

Health Hazard

The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1].

References

[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.

Properties of (R)-(-)-3-Chloro-1,2-propanediol

Melting point:	-40°C
Boiling point:	213 °C(lit.)
alpha	-0.9 º (neat)
Density	1.321 g/mL at 20 °C(lit.)
vapor pressure	0.04 mm Hg ( 25 °C)
refractive index	n20/D 1.48(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Chloroform, Methanol
form	clear liquid
pka	13.28±0.20(Predicted)
color	Colorless to Brown
Specific Gravity	1.322
optical activity	[α]20/D 1°, neat
Water Solubility	soluble
BRN	2202928
CAS DataBase Reference	57090-45-6(CAS DataBase Reference)

Safety information for (R)-(-)-3-Chloro-1,2-propanediol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H290:Corrosive to Metals H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H351:Carcinogenicity H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P234:Keep only in original container. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.