(R)-(-)-1-METHOXY-2-PROPANOL

Synonym(s):(R)-(−)-Propylene glycol 1-methyl ether

CAS NO.：4984-22-9
Empirical Formula: C4H10O2
Molecular Weight: 90.12
MDL number: MFCD01632587
EINECS: 628-460-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-17 21:30:02

What is (R)-(-)-1-METHOXY-2-PROPANOL?

Chemical properties

Colorless to light yellow liqui

The Uses of (R)-(-)-1-METHOXY-2-PROPANOL

(R)-(-)-1-Methoxy-2-propanol can be used as a reactant to prepare:

(S)-3-(ethoxycarbonyl)-5-((1-methoxypropan-2-yl)oxy)benzoic acid, a key intermediate to synthesize phenylethyl benzamide derivatives, which can be used as glucokinase activators.
Chiral pyrazolopyrimidinone derivatives as potential phosphodiesterase enzyme (PDE5) inhibitors.
Aryl or alkyl ethers via etherification reaction.

General Description

(R)-(-)-1-Methoxy-2-propanol is a chiral secondary alcohol. It is formed during the hydrolysis of (R)-1-methoxy-2-propyl-acetate in the presence of Candida antarctica lipase B.

Properties of (R)-(-)-1-METHOXY-2-PROPANOL

Melting point:	-97 °C
Boiling point:	119-121 °C (lit.)
Density	0.921 g/mL at 20 °C (lit.)
refractive index	n20/D 1.403
Flash point:	33 °C
storage temp.	Sealed in dry,2-8°C
form	Liquid
pka	14.49±0.20(Predicted)
color	Clear colorless
optical activity	[α]20/D 22±2°, c = 10% in chloroform
BRN	1718941
CAS DataBase Reference	4984-22-9(CAS DataBase Reference)

Safety information for (R)-(-)-1-METHOXY-2-PROPANOL

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H226:Flammable liquids H320:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool.