(R)-(-)-1-METHOXY-2-PROPANOL
Synonym(s):(R)-(−)-Propylene glycol 1-methyl ether
- CAS NO.：4984-22-9
- Empirical Formula: C4H10O2
- Molecular Weight: 90.12
- MDL number: MFCD01632587
- EINECS: 628-460-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-17 21:30:02
What is (R)-(-)-1-METHOXY-2-PROPANOL?
Chemical properties
Colorless to light yellow liqui
The Uses of (R)-(-)-1-METHOXY-2-PROPANOL
(R)-(-)-1-Methoxy-2-propanol can be used as a reactant to prepare:
- (S)-3-(ethoxycarbonyl)-5-((1-methoxypropan-2-yl)oxy)benzoic acid, a key intermediate to synthesize phenylethyl benzamide derivatives, which can be used as glucokinase activators.
- Chiral pyrazolopyrimidinone derivatives as potential phosphodiesterase enzyme (PDE5) inhibitors.
- Aryl or alkyl ethers via etherification reaction.
General Description
(R)-(-)-1-Methoxy-2-propanol is a chiral secondary alcohol. It is formed during the hydrolysis of (R)-1-methoxy-2-propyl-acetate in the presence of Candida antarctica lipase B.
Properties of (R)-(-)-1-METHOXY-2-PROPANOL
| Melting point: | -97 °C |
| Boiling point: | 119-121 °C (lit.) |
| Density | 0.921 g/mL at 20 °C (lit.) |
| refractive index | n |
| Flash point: | 33 °C |
| storage temp. | Sealed in dry,2-8°C |
| form | Liquid |
| pka | 14.49±0.20(Predicted) |
| color | Clear colorless |
| optical activity | [α]20/D 22±2°, c = 10% in chloroform |
| BRN | 1718941 |
| CAS DataBase Reference | 4984-22-9(CAS DataBase Reference) |
Safety information for (R)-(-)-1-METHOXY-2-PROPANOL
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02 |
| GHS Hazard Statements |
H226:Flammable liquids H320:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for (R)-(-)-1-METHOXY-2-PROPANOL
| InChIKey | ARXJGSRGQADJSQ-SCSAIBSYSA-N |
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