(R)-(+)-1-(4-PYRIDYL)ETHANOL
Synonym(s):(R)-(+)-1-(4-Pyridyl)ethanol
- CAS NO.：27854-88-2
- Empirical Formula: C7H9NO
- Molecular Weight: 123.15
- MDL number: MFCD00077865
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (R)-(+)-1-(4-PYRIDYL)ETHANOL?
Chemical properties
White needles
The Uses of (R)-(+)-1-(4-PYRIDYL)ETHANOL
(1R)-1-(4-Pyridyl)ethanol is a building block reagent used in the synthesis of potent GPR119 receptor agonists used in the treatment of diabetes.
Purification Methods
Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]
Properties of (R)-(+)-1-(4-PYRIDYL)ETHANOL
| Melting point: | 67-69 °C(lit.) |
| Boiling point: | 239.7±15.0 °C(Predicted) |
| Density | 1.082±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | soluble in Methanol |
| form | Crystalline Powder or Needles |
| pka | 13.52±0.20(Predicted) |
| color | White |
| optical activity | [α]20/D +55°, c = 1 in chloroform |
| BRN | 4306037 |
Safety information for (R)-(+)-1-(4-PYRIDYL)ETHANOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(+)-1-(4-PYRIDYL)ETHANOL
| InChIKey | HVOAMIOKNARIMR-ZCFIWIBFSA-N |
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