Quinapril hydrochloride

Synonym(s):(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride;Quinapril hydrochloride

CAS NO.：82586-55-8
Empirical Formula: C25H31ClN2O5
Molecular Weight: 474.98
MDL number: MFCD00889215
EINECS: 620-479-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Quinapril hydrochloride ?

Chemical properties

White Crystalline Solid

The Uses of Quinapril hydrochloride

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.

The Uses of Quinapril hydrochloride

Antihypertensive;Dopamine receptor agonist

The Uses of Quinapril hydrochloride

Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

What are the applications of Application

Quinapril Hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor

Definition

ChEBI: Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+).

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) .

General Description

Quinapril hydrochloride,(S)-[(S)-N-[(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hydrochloride(Acuretic), forms the diacid quinaprilate in thebody. It is more potent than captopril and equipotent to theactive form of enalapril.

Biochem/physiol Actions

Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

Properties of Quinapril hydrochloride

Melting point:	120-130°C
alpha	D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls)
storage temp.	2-8°C
solubility	H2O: >10mg/mL
form	solid
color	white
CAS DataBase Reference	82586-55-8(CAS DataBase Reference)

Safety information for Quinapril hydrochloride

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H303:Acute toxicity,oral H361:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P270:Do not eat, drink or smoke when using this product. P281:Use personal protective equipment as required. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. P403:Store in a well-ventilated place.