Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

Homecas82586-55-8

82586-55-8

82586-55-8 structural image
Product Name: Quinapril hydrochloride
Formula: C25H31ClN2O5
Synonyms: (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride;Quinapril hydrochloride
Inquiry

CHEMICAL AND PHYSICAL PROPERTIES

Melting Point 120-130 °C (crystals from ethyl acetatetoluene) and 119-121.5 °C (crystals from acetonitrile)
Solubility >71.2 [ug/mL] (The mean of the results at pH 7.4)
Collision Cross Section 203.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Other Experimental Properties Crystals from ethyl acetate-toluene ... /with/ specific optical rotation at 23 °C for D (sodium) line = +14.5 deg (c = 1.2 in ethanol). Also reported as white crystalline solid from acetonitrile ... /with/ specific optical rotation at 25 °C for D (sodium) line = +15.4 deg (c = 2 in methanol).

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Health Hazard
GHS08
GHS Hazard Statements H303:Acute toxicity,oral
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P270:Do not eat, drink or smoke when using this product.
P281:Use personal protective equipment as required.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P403:Store in a well-ventilated place.

COMPUTED DESCRIPTORS

Molecular Weight 475.0 g/mol
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 10
Exact Mass 474.1921498 g/mol
Monoisotopic Mass 474.1921498 g/mol
Topological Polar Surface Area 95.9 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 648
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+).

RELATED SUPPLIERS

Hetero Drugs Limited

1Y
product:82586-55-8 Quinapril hydrochloride 98%

Aarti Industries Limited (AIL)

1Y
product:82586-55-8 98%

HRV Global Life Sciences

1Y
product:Quinapril hydrochloride 99%

Alfa Omega Pharma

1Y
product:Quinapril hydrochloride 82586-55-8 98%

Ethachem

Maharashtra
product:Quinapril hydrochloride

DM Pharma

Tamil Nadu
product:Quinapril hydrochloride
All suppliers(6)