Quetiapine fumarate
Synonym(s):2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;Quetiapine fumarate;Quetiapine hemifumarate salt
- CAS NO.:111974-72-2
- Empirical Formula: C25H29N3O6S
- Molecular Weight: 499.58
- MDL number: MFCD03423782
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is Quetiapine fumarate?
Description
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively. Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model. Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.
Chemical properties
White Crystalline Solid
The Uses of Quetiapine fumarate
Used as an antipsychotic. Quetiapine fumarate is a psychotropic agent belonging to a chemical class, the dibenzothiazepine derivatives. It is present in tablets as the fumarate salt. It's activity is primarily due to the parent drug. Quetiapine has affinity for D2, 5-HT2A, H1, alpha 1 and 5-HT1A receptors.
The Uses of Quetiapine fumarate
antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
The Uses of Quetiapine fumarate
Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.
brand name
Seroquel (AstraZeneca).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Hazard
Human systemic effects.
Biochem/physiol Actions
Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
in vitro
quetiapine has shown affinity for various neurotransmitter receptorsincluding dopamine, serotonin, histamine, and adrenergicreceptors, quetiapine exihibited binding characteristics at the dopamine-2receptorsimilar to those of clozapine [1].
in vivo
in animal models, quetiapine exihibited a preclinical profile suggestive of antipsychotic activity with a reduced tendency to cause extrapyramidal symptoms (eps) and sustained prolactin elevation. quetiapine altered neurotensin neurotransmission and c-fos expression in limbic but not motor brain regions.in humans, quetiapine exhibited linear pharmacokinetics with a mean terminal half-life of 7 hours.the optimal dosing range for quetiapine was 150 to 750 mg/day, and recent results suggested that once-daily dosing might be suitable for some patients [1].quetiapine prevented schizophrenia and depression in hippocampal cell proliferation and bdnf expression caused by chronic restraint stress (crs) in rats in a dose-dependent manner. quetiapine (5 mg/kg) in combination with venlafaxine (2.5 mg/kg) increaseed hippocampal cell proliferation and prevented bdnf decrease in stressed rats, while each of the drugs exerted mild or no effects [2].in rats subjected to chronic-restraint stress, chronic administration of quetiapine attenuated the decrease in levels of brain-derived neurotrophic factor (bdnf) in the hippocampi. the stress-induced suppression of hippocampal neurogenesis was reversed after post-stress administration of quetiapine (10 mg/kg) for 7 or 21 days, evidenced in the numbers of pcreb-positive and brdu-labeled cells that were comparable to those in non-stressed rats but higher than those in the vehicle-treated rats [3].
storage
+4°C
References
1) Ellenbroek et al. (1996); Activity of “seroquel” (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine; Neuropsychopharmacology 15 406 2) Saller and Salama (1993), Seroquel: biochemical profile of a potential atypical antipsychotic; Psychopharmacolgy (Berl) 112 285 3) Ignacio et al. (2017), Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation; Behav. Brain Res. 320 225 4) Villarreal et al. (2016), Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial; Am. J. Psychiatry 173 1205
Properties of Quetiapine fumarate
Melting point: | 174-176°C |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | DMSO: >10mg/mL |
form | powder |
color | white to off-white |
Merck | 14,8039 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 111974-72-2(CAS DataBase Reference) |
Safety information for Quetiapine fumarate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Quetiapine fumarate
Abamectin manufacturer
Flax Laboratories
Vadivarhe Speciality Chemicals Limited
KARUNESH REMEDIES
Cefa-Cilinas Biotics Pvt Ltd
KARPSCHEM LABORATORIES PVT. LTD.
SOLISOM HEALTHCARE LLP
Synaptics Labs Private Limited
Dishman Carbogen Amcis Ltd (Dishman Group)
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