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HomeProduct name listPYRILAMINE

PYRILAMINE

  • CAS NO.:91-84-9
  • Empirical Formula: C17H23N3O
  • Molecular Weight: 285.38
  • MDL number: MFCD00023451
  • EINECS: 202-102-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
PYRILAMINE Structural

What is PYRILAMINE?

Toxicity

The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.

The Uses of PYRILAMINE

Pyrilamine is also used for allergy symptoms and rhinitis.

The Uses of PYRILAMINE

Antihistaminic.

The Uses of PYRILAMINE

N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine also known as pyrilamine works in synergism with diclofenac as a therapeutic alternative for clinical management of inflammatory pain.

Background

Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.

Definition

ChEBI: An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.

Indications

Indicated for the treatment of allergic conditions, symptomatic relief of hypersensitivity reaction, and treatment of pruritic skin disorders.

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037

General Description

Viscous brown liquid.

Air & Water Reactions

May be sensitive to light. Insoluble in water.

Reactivity Profile

PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.

Fire Hazard

Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.

Metabolism

Not Available

Properties of PYRILAMINE

Melting point: 131-132 °C
Boiling point: bp5 201°; bp0.06 168-172°
Density  1.0141 (rough estimate)
refractive index  nD25 1.5760-1.5765
pka pKa 4.02(H2O t=25 c=0.002 to 0.01) (Uncertain);8.92 (Uncertain)
Water Solubility  3.425g/L(37.5 ºC)
EPA Substance Registry System Mepyramine (91-84-9)

Safety information for PYRILAMINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PYRILAMINE

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