PYRILAMINE
- CAS NO.:91-84-9
- Empirical Formula: C17H23N3O
- Molecular Weight: 285.38
- MDL number: MFCD00023451
- EINECS: 202-102-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is PYRILAMINE?
Toxicity
The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.
The Uses of PYRILAMINE
Pyrilamine is also used for allergy symptoms and rhinitis.
The Uses of PYRILAMINE
Antihistaminic.
The Uses of PYRILAMINE
N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine also known as pyrilamine works in synergism with diclofenac as a therapeutic alternative for clinical management of inflammatory pain.
Background
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Indications
Indicated for the treatment of allergic conditions, symptomatic relief of hypersensitivity reaction, and treatment of pruritic skin disorders.
Definition
ChEBI: An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
brand name
Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037
General Description
Viscous brown liquid.
Air & Water Reactions
May be sensitive to light. Insoluble in water.
Reactivity Profile
PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.
Fire Hazard
Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.
Metabolism
Not Available
Properties of PYRILAMINE
Melting point: | 131-132 °C |
Boiling point: | bp5 201°; bp0.06 168-172° |
Density | 1.0141 (rough estimate) |
refractive index | nD25 1.5760-1.5765 |
pka | pKa 4.02(H2O
t=25
c=0.002 to 0.01) (Uncertain);8.92 (Uncertain) |
Water Solubility | 3.425g/L(37.5 ºC) |
EPA Substance Registry System | Mepyramine (91-84-9) |
Safety information for PYRILAMINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PYRILAMINE
Abamectin manufacturer
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