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HomeProduct name listPrunetin

Prunetin

Synonym(s):4′,5-Dihydroxy-7-methoxyisoflavone

  • CAS NO.:552-59-0
  • Empirical Formula: C16H12O5
  • Molecular Weight: 284.26
  • MDL number: MFCD00016951
  • EINECS: 209-018-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Prunetin Structural

What is Prunetin?

The Uses of Prunetin

Prunetin is isoflavone with diverse biological activities. Prunetin is an antagonist of the progesterone receptor when used at concentrations of 25 and 50 μM.

Definition

ChEBI: A hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group.

Enzyme inhibitor

This Prunus species isoflavone (FW = 284.27 g/mol; CAS 552-59-0; melting point = 240°C), also known as 4’,5-dihydroxy-7- methoxyisoflavone and 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1- benzopyran-4-one, inhibits alcohol dehydrogenase, aldehyde dehydrogenase, 3’,5’-cyclic-nucleotide phosphodiesterase, phosphodiesterase 4, and protein-tyrosine kinase. Its 4’-glucoside is prunitrin. Methylated isoflavones, such as prunetin, are rapidly converted by CYP1A2 to more active genistein and daidzein, which inhibit.formation of acetaminophen from phenacetin with an IC50 value of 16 μM.

Properties of Prunetin

Melting point: 240-242°C
Boiling point: 346.76°C (rough estimate)
Density  1.2160 (rough estimate)
refractive index  1.6200 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Powder
pka 6.35±0.20(Predicted)
color  White to off-white
BRN  292155
CAS DataBase Reference 552-59-0(CAS DataBase Reference)

Safety information for Prunetin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Prunetin

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