Prunetin

Synonym(s):4′,5-Dihydroxy-7-methoxyisoflavone

CAS NO.：552-59-0
Empirical Formula: C16H12O5
Molecular Weight: 284.26
MDL number: MFCD00016951
EINECS: 209-018-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Prunetin?

The Uses of Prunetin

Prunetin is isoflavone with diverse biological activities. Prunetin is an antagonist of the progesterone receptor when used at concentrations of 25 and 50 μM.

Definition

ChEBI: A hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group.

Enzyme inhibitor

This Prunus species isoflavone (FW = 284.27 g/mol; CAS 552-59-0; melting point = 240°C), also known as 4’,5-dihydroxy-7- methoxyisoflavone and 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1- benzopyran-4-one, inhibits alcohol dehydrogenase, aldehyde dehydrogenase, 3’,5’-cyclic-nucleotide phosphodiesterase, phosphodiesterase 4, and protein-tyrosine kinase. Its 4’-glucoside is prunitrin. Methylated isoflavones, such as prunetin, are rapidly converted by CYP1A2 to more active genistein and daidzein, which inhibit.formation of acetaminophen from phenacetin with an IC50 value of 16 μM.

Properties of Prunetin

Melting point:	240-242°C
Boiling point:	346.76°C (rough estimate)
Density	1.2160 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	6.35±0.20(Predicted)
color	White to off-white
BRN	292155
CAS DataBase Reference	552-59-0(CAS DataBase Reference)

Safety information for Prunetin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.